2nd International Conference on AI, Machine Learning and Data Science (AIMDS 2025) will be an exceptional virtual platform for sharing knowledge and research findings in the theory, methodology, and applications of AI, Machine Learning, and Data Science. AIMDS 2025 emphasizes both theoretical research and practical applications in these fields. The conference seeks high-quality papers that address all technical aspects of AI, Machine Learning, and Data Science. Submissions from academia, industry, and government are encouraged, covering both traditional and emerging topics, as well as innovative paradigms, with a strong focus on real-world problems, systems and applications.